For a long time, it has been known that at least 40 percent of cancer cases are due to modifiable risk factors such as smoking, unhealthy diet, alcohol consumption, lack of exercise, and obesity. Many more cancer cases or cancer deaths could be prevented through the implementation of screening measures. However, mere knowledge of the potential of cancer prevention is not sufficient. Rather, there is a need to develop and evaluate strategies to effectively implement cancer prevention in the population. Target group-specific approaches are particularly promising in this regard. Consideration of different living situations and life stages is also crucial. The prevention measures should be designed pragmatically using existing structures. Precisely for this type of implementation research, we are initiating the model region Bremen as part of the National Decade against Cancer . With this project, we want to demonstrate ways to fully and sustainably utilize the potential of cancer prevention and early detection at the regional level.