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Pooled analysis of European case-control studies on the interaction of occupational carcinogens in the development of lung cancer

Description

The SYNERGY project -a pooled analysis of case-control studies on the joint effects of occupational carcinogens in the development of lung cancer- began in January 2007. The aim of SYNERGY is to study joint effects of occupational lung carcinogens and smoking. The SYNERGY project has collected individual lifetime data on occupations and smoking history for approximately 18.000 lung cancer cases and >22.000 control subjects. This database provides the best available tool for estimating the joint effect of occupational carcinogens.

As one of 14 case-control-studies the BIPS contributes 1004 cases and 1004 controls from the HdA-Study.

Until the end of 2016, 11 scientific papers could be published in international, high-ranking peer reviewed journals. The IARC is currently trying to obtain further funding in order to continue this cooperation project.

Funding period

Begin:   April 2007
End:   March 2011

Sponsor

  • International Agency for the Research on Cancer (IARC)

Contact

Dr. rer. medic. Hermann Pohlabeln

Project management (international)

Dr. Kurt Straif, IARC, Lyon, Frankreich

Cooperation

  • Department of Human Oncology and Center for Oncologic Prevention, Turin/Italien
  • Environmental and Occupational Health Division, Institute for Risk Assessment Sciences (IRAS) der Universität, Utrecht/Niederlande
  • GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Neuherberg
  • Inst. für Medizin. Informatik, Biometrie & Epidemiologie, Universität Essen
  • International Agency for Research on Cancer (IARC), Lyon/Frankreich
  • Karolinska Institut, Stockholm/Schweden
  • Unit of Epidemiology, Department of Preventive Medicine, Clinica del Lavoro, Mailand/Italien

Selected project-related publications

    Articles with peer-review

  • Olsson AC, Vermeulen R, Schüz J, Kromhout H, Pesch B, Peters S, Behrens T, Portengen L, Mirabelli D, Gustavsson P, Kendzia B, Almansa J, Luzon V, Vlaanderen J, Stücker I, Guida F, Consonni D, Caporaso N, Landi MT, Field J, Brüske I, Wichmann H-E, Siemiatycki J, Parent M-E, Richiardi L, Merletti F, Jöckel K-H, Ahrens W, Pohlabeln H, Plato N, Tardón A, Zaridze D, McLaughlin J, Demers P, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Dumitru RS, Bencko V, Foretova L, Janout V, Boffetta P, Bueno-de-Mesquita HB, Forastiere F, Brüning T, Straif K. Exposure-response analyses of asbestos and lung cancer subtypes in a pooled analysis of case-control studies. Epidemiology. 2017;28(2):288-299.
    https://doi.org/10.1097/EDE.0000000000000604
  • Behrens T, Gross IM, Siemiatycki J, Conway DI, Olsson A, Stücker I, Guida F, Jöckel K-H, Pohlabeln H, Ahrens W, Brüske I, Wichmann H-E, Gustavsson P, Consonni D, Merletti F, Richiardi L, Simonato L, Fortes C, Parent M-E, McLaughlin J, Demers P, Landi MT, Caporaso N, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Fabianova E, Tardón A, Field JK, Dumitru RS, Bencko V, Foretova L, Janout V, Kromhout H, Vermeulen R, Boffetta P, Straif K, Schüz J, Hovanec J, Kendzia B, Pesch B, Brüning T. Occupational prestige, social mobility and the association with lung cancer in men. BMC Cancer. 2016;16:395.
    https://doi.org/10.1186/s12885-016-2432-9
  • Bigert C, Gustavsson P, Straif K, Taeger D, Pesch B, Kendzia B, Schüz J, Stücker I, Guida F, Brüske I, Wichmann H-E, Pesatori A, Landi MT, Caporaso N, Tse LA, Yu IT-s, Siemiatycki J, Lavoué J, Richiardi L, Mirabelli D, Simonato L, Jöckel K-H, Ahrens W, Pohlabeln H, Tardón A, Zaridze D, Field JK, 't Mannetje A, Pearce N, McLaughlin J, Demers P, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Stanescu Dumitru R, Bencko V, Foretova L, Janout V, Boffetta P, Peters S, Vermeulen R, Kromhout H, Brüning T, Olsson AC. Lung cancer among firefighters: Smoking-adjusted risk estimates in a pooled analysis of case-control studies. Journal of Occupational and Environmental Medicine. 2016;58(11):1137-1143.
    https://doi.org/10.1097/JOM.0000000000000878
  • Bigert C, Gustavsson P, Straif K, Pesch B, Brüning T, Kendzia B, Schüz J, Stücker I, Guida F, Brüske I, Wichmann H-E, Pesatori A, Landi MT, Caporaso N, Tse LA, Yu IT-s, Siemiatycki J, Pintos J, Merletti F, Mirabelli D, Simonato L, Jöckel K-H, Ahrens W, Pohlabeln H, Tardón A, Zaridze D, Field J, 't Mannetje A, Pearce N, McLaughlin J, Demers P, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Stanescu Dumitru R, Bencko V, Foretova L, Janout V, Boffetta P, Forastiere F, Bueno-de-Mesquita HB, Peters S, Vermeulen R, Kromhout H, Olsson AC. Lung cancer risk among cooks when accounting for tobacco smoking: A pooled analysis of case-control studies from Europe, Canada, New Zealand, and China. Journal of Occupational and Environmental Medicine. 2015;57(2):202-209.
    https://doi.org/10.1097/JOM.0000000000000337
  • Consonni D, De Matteis S, Pesatori A, Bertazzi PA, Olsson A, Kromhout H, Peters S, Vermeulen R, Pesch B, Brüning T, Kendzia B, Behrens T, Stücker I, Guida F, Wichmann H-E, Brüske I, Landi MT, Caporaso N, Gustavsson P, Plato N, Tse LA, Yu IT-s, Jöckel K-H, Ahrens W, Pohlabeln H, Merletti F, Richiardi L, Simonato L, Forastiere F, Siemiatycki J, Parent M-E, Tardón A, Boffetta P, Zaridze D, Chen Y, Field J, 't Mannetje A, Pearce N, McLaughlin J, Demers P, Lissowska J, Szeszenia-Dabrowska N, Bencko V, Foretova L, Janout V, Rudnai P, Fabianova E, Stanescu Dumitru R, Bueno-de-Mesquita HB, Schüz J, Straif K. Lung cancer risk among bricklayers in a pooled analysis of case-control studies. International Journal of Cancer. 2015;136(2):360-371.
    https://doi.org/10.1002/ijc.28986
  • Taeger D, Pesch B, Kendzia B, Behrens T, Jöckel K-H, Dahmann D, Siemiatycki J, Kromhout H, Vermeulen R, Peters S, Olsson A, Brüske I, Wichmann H-E, Stücker I, Guida F, Tardón A, Merletti F, Mirabelli D, Richiardi L, Pohlabeln H, Ahrens W, Landi MT, Caporaso N, Pesatori A, Mukeria A, Szeszenia-Dabrowska N, Lissowska J, Gustavsson P, Field J, Marcus M, Fabianova E, 't Mannetje A, Pearce N, Rudnai P, Bencko V, Janout V, Dumitru RS, Foretova L, Forastiere F, McLaughlin J, Demers P, Bueno-de-Mesquita HB, Schüz J, Straif K, Brüning T. Lung cancer among coal miners, ore miners and quarrymen: Smoking-adjusted risk estimates from the synergy pooled analysis of case-control studies. Scandinavian Journal of Work, Environment & Health. 2015;41(5):467-477.
    https://doi.org/10.5271/sjweh.3513
  • Denholm R, Schüz J, Straif K, Stücker I, Jöckel K-H, Brenner DR, De Matteis S, Boffetta P, Guida F, Brüske I, Wichmann H-E, Landi MT, Caporaso N, Siemiatycki J, Ahrens W, Pohlabeln H, Zaridze D, Field JK, McLaughlin J, Demers P, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Stanescu Dumitru R, Bencko V, Foretova L, Janout V, Kendzia B, Peters S, Behrens T, Vermeulen R, Brüning T, Kromhout H, Olsson A. Is previous respiratory disease a risk factor for lung cancer? American Journal of Respiratory and Critical Care Medicine. 2014;190(5):549-559.
    https://doi.org/10.1164/rccm.201402-0338OC
  • Vlaanderen J, Portengen L, Schüz J, Olsson A, Pesch B, Kendzia B, Stücker I, Guida F, Brüske I, Wichmann H-E, Consonni D, Landi MT, Caporaso N, Siemiatycki J, Merletti F, Mirabelli D, Richiardi L, Gustavsson P, Plato N, Jöckel K-H, Ahrens W, Pohlabeln H, Tardón A, Zaridze D, Field JK, 't Mannetje A, Pearce N, McLaughlin J, Demers P, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Stanescu Dumitru R, Bencko V, Foretova L, Janout V, Boffetta P, Forastiere F, Bueno-de-Mesquita HB, Peters S, Brüning T, Kromhout H, Straif K, Vermeulen R. Effect modification of the association of cumulative exposure and cancer risk by intensity of exposure and time since exposure cessation: A flexible method applied to cigarette smoking and lung cancer in the SYNERGY study. American Journal of Epidemiology. 2014;179(3):290-298.
    https://doi.org/10.1093/aje/kwt273
  • Kendzia B, Behrens T, Jöckel K-H, Siemiatycki J, Kromhout H, Vermeulen R, Peters S, van Gelder R, Olsson A, Brüske I, Wichmann H-E, Stücker I, Guida F, Tardón A, Merletti F, Mirabelli D, Richiardi L, Pohlabeln H, Ahrens W, Landi MT, Caporaso N, Consonni D, Zaridze D, Szeszenia-Dabrowska N, Lissowska J, Gustavsson P, Marcus M, Fabianova E, 't Mannetje A, Pearce N, Tse LA, Yu IT-s, Rudnai P, Bencko V, Janout V, Mates D, Foretova L, Forastiere F, McLaughlin J, Demers P, Bueno-de-Mesquita HB, Boffetta P, Schüz J, Straif K, Pesch B, Brüning T. Welding and lung cancer in a pooled analysis of case-control studies. American Journal of Epidemiology. 2013;178(10):1513-1525.
    https://doi.org/10.1093/aje/kwt201
  • Olsson AC, Xu Y, Schüz J, Vlaanderen J, Kromhout H, Vermeulen R, Peters S, Stücker I, Guida F, Brüske I, Wichmann H-E, Consonni D, Landi MT, Caporaso N, Tse LA, Yu IT-s, Siemiatycki J, Richardson L, Mirabelli D, Richiardi L, Simonato L, Gustavsson P, Plato N, Jöckel K-H, Ahrens W, Pohlabeln H, Tardón A, Zaridze D, Marcus M, 't Mannetje A, Pearce N, McLaughlin J, Demers P, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Stanescu Dumitru R, Bencko V, Foretova L, Janout V, Boffetta P, Fortes C, Bueno-de-Mesquita HB, Kendzia B, Behrens T, Pesch B, Brüning T, Straif K. Lung cancer risk among hairdressers - A pooled analysis of case-control studies conducted between 1985 and 2010. American Journal of Epidemiology. 2013;178(9):1355-1365.
    https://doi.org/10.1093/aje/kwt119
  • Pesch B, Kendzia B, Gustavsson P, Jöckel K-H, Johnen G, Pohlabeln H, Olsson A, Ahrens W, Gross IM, Brüske I, Wichmann H-E, Merletti F, Richiardi L, Simonato L, Fortes C, Siemiatycki J, Parent M-E, Consonni D, Landi MT, Caporaso N, Zaridze D, Cassidy A, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Stücker I, Fabianova E, Stanescu Dumitru R, Bencko V, Foretova L, Janout V, Rudin CM, Brennan P, Boffetta P, Straif K, Brüning T. Cigarette smoking and lung cancer - relative risk estimates for the major histological types from a pooled analysis of case-control studies. International Journal of Cancer. 2012;131(5):1210-1219.
    https://doi.org/10.1002/ijc.27339
  • Olsson AC, Gustavsson P, Kromhout H, Peters S, Vermeulen R, Brüske I, Pesch B, Siemiatycki J, Pintos J, Brüning T, Cassidy A, Wichmann H-E, Consonni D, Landi MT, Caporaso N, Plato N, Merletti F, Mirabelli D, Richiardi L, Jöckel K-H, Ahrens W, Pohlabeln H, Lissowska J, Szeszenia-Dabrowska N, Zaridze D, Stücker I, Benhamou S, Bencko V, Foretova L, Janout V, Rudnai P, Fabianova E, Stanescu Dumitru R, Gross IM, Kendzia B, Forastiere F, Bueno-de-Mesquita HB, Brennan P, Boffetta P, Straif K. Exposure to diesel motor exhaust and lung cancer risk in a pooled analysis from case-control studies in Europe and Canada. American Journal of Respiratory and Critical Care Medicine. 2011;183(7):941-948.
    https://doi.org/10.1164/rccm.201006-0940OC