Epidemiological database study investigating the risk of diabetic complications in type 2 diabetes patients treated with different antidiabetics
Description
- Cardiovascular diseases are the most common comorbidities in diabetics and account for the high morbidity and mortality among these patients. Several studies emphasised the role of a proper antidiabetic treatment for the cardiovascular risk. In particular, high values of glycolised haemoglobin (HbA1c) are associated with an increased cardiovascular risk. The ability to control HbA1c varies for different basal insulins. Contrary to the USA, data from epidemiological studies in Germany was lacking. To close this gap, a cohort study based on administrative data from German statutory health insurances included in the German Pharmacoepidemiological Research Database (GePaRD) was conducted. This study investigated the risk of acute myocardial infarction in type 2 diabetic patients treated with different basal insulins (long-acting analogue insulin, human NPH insulin and premixed insulin). The analyses revealed no difference in the risk for acute myocardial infarction between the basal insulins. However, since the period of observation was relatively short, further studies are required to assess long-term effects of the basal insulins.
Funding period
- Begin: March 2010
End: June 2012
Sponsor
- Pharmaceutical industry
Contact
Selected project-related publications
- Kollhorst B, Behr S, Enders D, Dippel F-W, Theobald K, Garbe E. Comparison of basal insulin therapies with regard to the risk of acute myocardial infarction in patients with type 2 diabetes: An observational cohort study. Diabetes, Obesity & Metabolism. 2015;17(12):1158-1165.
https://doi.org/10.1111/dom.12554 - Enders D, Behr S. Finding the optimal propensity score model - Experiences from a study comparing the risk of myocardial infarction in different insulin treatment groups. 5. Workshop der Arbeitsgemeinschaft Pharmakoepidemiologie der Deutschen Gesellschaft für Epidemiologie (DGEpi) und der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS), 14.-15. Juni 2012, Bremen.
- Behr S, Kollhorst B, Enders D, Timmer A, Dippel F-W, Theobald K, Garbe E. Risk of acute myocardial infarction in patients with diabetes mellitus type 2 treated with different basal insulins. 29th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE), 25-28 August 2013, Montreal, Canada.
- Behr S, Kollhorst B, Dittmann U, Enders D, Timmer A, Dippel F-W, Theobald K, Garbe E. Risk of acute myocardial infarction in patients with diabetes mellitus type 2 treated with basal insulin. 7. Jahrestagung der Deutschen Gesellschaft für Epidemiologie (DGEpi), 26.-29. September 2012, Regensburg.
- Enders D, Behr S, Kollhorst B, Dittmann U, Timmer A, Dippel F-W, Theobald K, Garbe E. Propensity score analysis to compare basal insulin treatment groups regarding the risk of acute myocardial infarction in type 2 diabetes mellitus. 57. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (GMDS), 16.-21. September 2012, Braunschweig.
- Behr S, Kollhorst B, Dippel F-W, Garbe E. Identification of patients with diabetes mellitus type 2 in insurance claims data - Are problems caused by ambiguous ICD-10 codes? 28th International Conference on Pharmacoepidemiology & Therapeutic Risk Management (ICPE), 23-26 August 2012, Barcelona, Spain. (Abstract published in: Pharmacoepidemiology & Drug Safety. 2012;21(Suppl.3):396)