Statistical Methods in Epidemiology

Biometry

The institute has been in the position to assemble biometricians experienced in a wide range of epidemiological studies (case control, cohort, cross-sectional, longitudinal, incidence studies, etc.) as permanent staff. For specific research projects, a number of short-term employees as well as postgraduate students (usually financed by third parties) extend the range of methods employed in the department. In this context the department also offers the opportunity to write a PhD thesis.

Methods development

We are presently working on diverse topics: these include statistical issues related to the pharmacoepidemiologic research database (twophase studies, control for confounding - Statistical Modeling of Secondary and Registry Data Unit), improvement of statistical procedures in the analysis of gene-gene- and gene-environment interactions, the identification of biological pathways involved in the development of diseases and in the statistical modeling of pathways, accumulations of risk or critical time periods in life-course epidemiology, statistical modeling of nutrition data and use of geographical information systems in epidemiologic studies (Statistical Modeling of Primary Data Unit). Furthermore, the department engages in the development of methods for causal inference, e.g. for instrumental variables or time-varying confounding (Statistical Methods for Causal Inference Research Group), and statistical machine learning (Emmy Noether Junior Research Group: Beyond Prediction - Statistical Inference). With the improved accessibility of research data, development of methods for analysis and combining data, for example by means of record linkage or distributed analyses, is increasingly important.

Statistical support - quantitative methods consulting service

The department also houses a methods consultancy service that is used BIPS-internally as well as externally by other research institutions and scientifically working clinicians, primarily from Bremen and the surrounding region. Support is mainly requested in the planning phase of studies e.g. on the selection of the study design or on sample size calculations. Appropriate analysis methods are proposed and/or developed and support in the application of methods as well as in the interpretation and presentation of results is provided.

Within the inter-departmental working group GeTTCausal (GePaRD & Target Trials for Causal Inference), we combine expertise in secondary data analysis, causal inference, and clinical epidemiology to best analyze important causal questions based on GePaRD using the "target trial emulation" (TTE) approach.

Staff

Bergen, Luca
Tel.: +49 (0)421 218-56796
bergen(at)leibniz-bips.de

Börnhorst, Claudia, Dr.
Tel.: +49 (0)421 218-56946
Fax: +49 (0)421 218-56941
boern(at)leibniz-bips.de

Braitmaier, Malte, Dr.
Tel.: +49 (0)421 218-56983
Fax: +49 (0)421 218-56941
braitmaier(at)leibniz-bips.de

Buck, Christoph, Dr.
Tel.: +49 (0)421 218-56944
Fax: +49 (0)421 218-56941
buck(at)leibniz-bips.de

Burk, Lukas
Tel.: +49 (0)421 218-56955
Fax: +49 (0)421 218-56941
burk(at)leibniz-bips.de

Didelez, Vanessa, Prof. Dr.
Tel.: +49 (0)421 218-56939
Fax: +49 (0)421 218-56941
didelez(at)leibniz-bips.de

Foraita, Ronja, Dr.
Tel.: +49 (0)421 218-56954
Fax: +49 (0)421 218-56941
foraita(at)leibniz-bips.de

Frielinghaus, Maria
Tel.: +49 (0)421 218-56791
Frielinghaus(at)leibniz-bips.de

Gabbert, Anja
Tel.: +49 (0)421 218-56934
Fax: +49 (0)421 218-56941
gabbert(at)leibniz-bips.de

Gesing, Nils Fabian
Tel.: +49 (0)421 218-56935
Fax: +49 (0)421 218-56941
gesing(at)leibniz-bips.de

Golchian, Pegah
Tel.: +49 (0)421 218-56790
golchian(at)leibniz-bips.de

Herbinger, Julia, Dr.
herbinger(at)leibniz-bips.de

Kapar, Jan
Tel.: +49 (0)421 218-56929
Fax: +49 (0)421 218-56941
kapar(at)leibniz-bips.de

Koenen, Niklas
Tel.: +49 (0)421 218-56933
Fax: +49 (0)421 218-5641
koenen(at)leibniz-bips.de

Kollhorst, Bianca, Dr.
Tel.: +49 (0)421 218-56980
Fax: +49 (0)421 218-56941
kollhorst(at)leibniz-bips.de

Kueté Fouodo, Césaire Joris, Dr.
Tel.: +49 (0)421 218-56867
fouodo(at)leibniz-bips.de

Langbein, Sophie
Tel.: +49 (0)421 218-56886
langbein(at)leibniz-bips.de

Ludewig, Alina
Tel.: +49 (0)421 218-56882
Fax: +49 (0)421 218-56941
ludewig(at)leibniz-bips.de

Niemeyer, Marieke
Tel.: +49 (0)421 218-56876
Fax: +49 (0)421 218-56941
niemeyer(at)leibniz-bips.de

Pohlabeln, Hermann, Dr.
Tel.: +49 (0)421 218-56947
Fax: +49 (0)421 218-56941
pohlabeln(at)leibniz-bips.de

Runge, Lea
Tel.: +49 (0)421 218-56979
runge(at)leibniz-bips.de

Schaffer, Inga
Tel.: +49 (0)421 218-56871
Fax: +49 (0)421 218-56941
schaffer(at)leibniz-bips.de

Viebrock, Jost
Tel.: +49 (0)421 218-56951
Fax: +49 (0)421 218-56941
viebrock(at)leibniz-bips.de

Volkmar, Philipp Alexander
Tel.: +49 (0)421 218-56948
Fax: +49 (0)421 218-56941
volkmar(at)leibniz-bips.de

Wright, Marvin N., Prof. Dr.
Tel.: +49 (0)421 218-56945
Fax: +49 (0)421 218-56941
wright(at)leibniz-bips.de

Zhang, Jiumeng
zhang(at)leibniz-bips.de

Departmental News

Public health rethought: Interdisciplinary handbook highlights opportunities and challenges of digitization in healthcare

A new, comprehensive handbook shows how digital technologies influence our health—and what new questions this raises. Edited by Prof. Dr. Hajo Zeeb and colleagues from Bremen, the work “Digital Public Health—Interdisciplinary Perspectives” brings together perspectives from health, information, and social sciences. It has now been published by Springer in the “Series on Epidemiology and Public Health.”

“I am very happy that this book is now available. It brings together the diverse insights and discussions that we have developed together at the Leibniz ScienceCampus Digital Public Health over the past few years,” says Prof. Dr. Hajo Zeeb, spokesperson for the Leibniz ScienceCampus Digital Public Health Bremen and head of department at the Leibniz Institute for Prevention Research and Epidemiology – BIPS.

Whether apps, smartwatches, or social media – digital technologies have become an integral part of everyday life. They are also having an impact in the field of public health: with their help, information can be disseminated in a more targeted manner, gaps in care can be closed, and the early detection of diseases can be supported. At the same time, they challenge existing concepts: How do we protect personal data? Which groups are reached—and which are left out? And what ethical, legal, or social consequences does digitization entail?

The handbook contains over 30 contributions from experts in medicine, epidemiology, psychology, philosophy, law, computer science, and other disciplines. The articles highlight both the potential and the risks of digital applications – from questions of digital health literacy and the ethical dilemmas of new technologies to concrete implementation in healthcare practice. One thing is clear: digitization is not an end in itself. It must be geared toward the actual needs of the population. This requires interdisciplinary cooperation, well-thought-out technological development, and consistent scientific monitoring.

“The special value of this book lies in its combination of theory, practice, and technology. It shows how important it is that digitization does not happen over people's heads, but on the basis of evidence, participation, and reflection,” says Zeeb.

The book is intended not only as a reference work for researchers, but also as a practical guide for professionals in administration, politics, and healthcare. It offers insights into current developments – such as the regulation of digital health applications, the handling of health data, and the design of digital prevention strategies. The central finding: only when different disciplines work together can digitization contribute to strengthening the health of the population in the long term. In order to make these findings accessible to a broad public, the book is being published as an open-access publication and is available online free of charge here. In order to reach an international audience, the book was written in English.

Funding information
The work was carried out as part of the Leibniz ScienceCampus Digital Public Health Bremen (www.digital-public-health.de). The campus is jointly funded by the Leibniz Association, the state of Bremen, and the Leibniz Institute for Prevention Research and Epidemiology – BIPS. The publication was also partially supported by the Leibniz Association's publication fund.

Original publication
Zeeb H, Maaß L, Schultz T, Haug U, Pigeot I, Schüz B (Eds.). Digital Public Health – Interdisciplinary Perspectives. Cham: Springer; 2025. (Springer Series on Epidemiology and Public Health). doi:10.1007/978-3-031-90154-6

BIPS – Health research in the service of people
The population is at the center of our research. As an epidemiological research institute, we see our task as identifying the causes of health problems and developing new concepts for the prevention of disease. Our research provides a basis for social decisions. It informs the population about health risks and contributes to a healthy living environment.

BIPS is a member of the Leibniz Association, which comprises 96 independent research institutions. The Leibniz Institutes cover a wide range of disciplines, from the natural sciences, engineering, and environmental sciences to economics, spatial sciences, social sciences, and the humanities. Leibniz Institutes are dedicated to socially, economically, and ecologically relevant issues. Due to their national significance, the federal and state governments jointly fund the institutes of the Leibniz Association. The Leibniz Institutes employ around 20,000 people, including 10,000 scientists. The total budget of the institutes is more than 1.9 billion euros.